The authors of this article show that, by their estimates, the public market for vaccines in Africa could rise from $1.3 billion today to between $2.3 billion and $5.4 billion by 2030 (depending on the scenario). While Africa’s population is growing faster than that of most other regions, significant immunization coverage gaps remain, and new products (such as vaccines for Lassa fever or malaria) could be introduced and used widely on the continent. Leaders are increasingly aware of the importance of health security, both for its own sake and as a critical tool for securing the continent’s development, and are increasingly heeding calls for investments into vaccine manufacturing to prevent African countries from being last in line for vital supplies.