Innovation should be a fully integrated part of Denmark’s healthcare system, both in cultural and operational terms, and researchers should find it worthwhile to pursue the development of new methods and solutions for improving patient care. This is the vision for a 5-year pilot project to be run by innovation centers at Rigshospitalet in Copenhagen and Aarhus University Hospital and with local innovation employees at Aalborg and Odense University Hospitals. The Novo Nordisk Foundation has awarded a grant of slightly more than DKK 128 million for the project.